Ontogeny of oscillatory slow-wave and neuronal population activity in human iPSC-3D cortical circuits

Julia Izsak, Stephan Theiss, Sebastian Illes Abstract Oscillatory slow-wave activity (0.5—100 Hz) emerges during fetal human cortex development reflecting functional consequences of cellular

Differential acute impact of therapeutically effective and overdose concentrations of lithium on human neuronal single cell and network function

Julia Izsak, Henrik Seth, Margarita Iljin, Stephan Theiss, Hans Ågren, Keiko Funa, Ludwig Aigner, Eric Hanse &  Sebastian Illes  Abstract Lithium salts are used as mood-balancing

Human Cerebrospinal Fluid Promotes Neuronal Circuit Maturation of Human Induced Pluripotent Stem Cell-Derived 3D Neural Aggregates

Julia Izsak, Henrik Seth, Stephan Theiss, Eric Hanse, Sebastian Illes Human induced pluripotent stem cell (hiPSC)-derived in vitro neural and organoid models resemble fetal, rather than

Robust Generation of Person-Specific, Synchronously Active Neuronal Networks Using Purely Isogenic Human iPSC-3D Neural Aggregate Cultures

Julia Izsak, Henrik Seth, Mats Andersson, Dzeneta Vizlin-Hodzic, Stephan Theiss, Eric Hanse, Hans Ågren, Keiko Funa, Sebastian Illes

Analysis and Modeling of Subthreshold Neural Multi-Electrode Array Data by Statistical Field Theory

Måns Henningson, Sebastian Illes Abstract Multi-electrode arrays (MEA) are increasingly used to investigate spontaneous neuronal network activity. The recorded

Intrinsically Active and Pacemaker Neurons in Pluripotent Stem Cell-Derived Neuronal Populations

Sebastian Illes, Martin Jakab, Felix Beyer, Renate Gelfert, Sébastien Couillard-Despres, Alfons Schnitzler, Markus Ritter, Ludwig Aigner Summary Neurons generated from pluripotent stem cells (PSCs) self-organize into functional neuronal assemblies in vitro, generating synchronous network

Cerebrospinal fluid of brain trauma patients inhibits in vitro neuronal network function via NMDA receptors

Frauke Otto MD, Sebastian Illes MSc, Jessica Opatz PhD, Maurice Laryea PhD, Stephan Theiss MSc, Hans-Peter Hartung MD, Alfons Schnitzler MD, Mario Siebler MD, Marcel Dihné

Niche-dependent development of functional neuronal networks from embryonic stem cell-derived neural populations

Sebastian Illes, Stephan Theiss, Hans-Peter Hartung, Mario Siebler, and Marcel Dihné Abstract Background The present work was performed to investigate the ability of

Development and pharmacological modulation of embryonic stem cell-derived neuronal network activity

Sebastian Illes, Wiebke Fleischer, Mario Siebler, Hans-Peter Hartung, Marcel Dihné Abstract Embryonic stem cells can be differentiated into neurons of diverse neurotransmitter-specific phenotypes. While the time course of